Metformin EP Impurity E 3/2Sulfate CAS 36801-25-9(free base)
| CAS No. | 36801-25-9(free base) |
| Molecular Formula | 3*C3H9N5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 213.21 g/mol gives Metformin EP Impurity E 3/2Sulfate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Metformin EP Impurity E 3/2Sulfate (CAS 36801-25-9(free base)) is a certified pharmaceutical impurity reference standard with the molecular formula C3H9N5H2O4S and a molecular weight of 213.21 g/mol.
Owing to an amide group, a sulfone group, a carboxylic acid group, an ether linkage, Metformin EP Impurity E 3/2Sulfate is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 213.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | 3*C3H9N5 2*H2O4S |
| Molecular Weight | 213.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 1.0 |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Metformin Standards
- Metformin EP Impurity D (CAS 108-78-1)
- Metformin Hydrochloride (CAS 1115-70-4)
- Metformin-d6 Hydrochloride (CAS 1185166-01-1)
- Metformin Impurity 38 (CAS 118632-64-7)
- Metformin EP impurity F Tetrahydrofuran Solution (CAS 124-40-3 (free base))
- Metformin Impurity 532 (CAS 141-83-3)
- Metformin Impurity N74 (CAS 1609-00-3)
- Metformin EP Impurity E HCl (CAS 1674-62-0)
Recommended Standards
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- 5-(3-Methoxyphenyl)-3-[5-phenyl-2-(1H-pyrrol-1-yl)furan-3-yl]-1,2,4-oxadiazole (CAS 866049-43-6)
- Febuxostat Impurity 96 (CAS CATO-C4X-116296)
- 4,5-Dibromothiophene-3-carboxylic acid (CAS 101079-66-7)
- Ethyl 2-oxo-2-((3-thioxo-3H-1,2,4-dithiazol-5-yl)amino)acetate (CAS 306980-72-3)
- [2-31]-Semaglutide C (x TFA Salt) (CAS CATO-C4X-2226118)
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